PD-166866

• Catalog No.: PZ0114
• CAS Number: 192705-79-6
• M. F.: C20H24N6O3
• M. W.: 396.44296
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
• IUPAC Traditional name: 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
• Synonyms: 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea

DATABASE IDS

• CAS Number: 192705-79-6
• MDL Number: MFCD12922514

PROPERTIES

• Empirical Formula (Hill Notation): C20H24N6O3
• Purity: ≥98% (HPLC)
• Apperance: off-white to light tan
• Solubility: DMSO: ≥10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Temperature: 2-8°C
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.
Legal Information
Sold for research purposes under agreement from Pfizer Inc.

Description (简体中文)

Biochem/physiol Actions
PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.
Legal Information
Sold for research purposes under agreement from Pfizer Inc.