Ro 60-0175

• Catalog No.: R0408
• M. F.: C15H16ClFN2O4
• M. W.: 342.7499432
• Purity: ≥99% (HPLC)

SYNONYMS

• IUPAC name: (2S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-amine; but-2-enedioic acid
• IUPAC Traditional name: (2S)-1-(6-chloro-5-fluoroindol-1-yl)propan-2-amine; butenedioic acid
• Synonyms: (aS)-6-Chloro-5-fluoro-a-methyl-1H-indole-1-ethanamine monofumarate

DATABASE IDS

• MDL Number: MFCD06798313

PROPERTIES

• Empirical Formula (Hill Notation): C11H12ClFN2 ·C4H4O4
• Purity: ≥99% (HPLC)
• Apperance: solid
• Solubility: deionized water: soluble10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Ro 60-0175 was originally reported to be a potent, selective 5-HT2C receptor agonist (with pKi values of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). That assignment has been questioned, however, supported by evidence from coadministration of Ro 60-0175 and SB 242084, a selective 5-HT2C antagonist.1

Description (简体中文)

Biochem/physiol Actions
Ro 60-0175 was originally reported to be a potent, selective 5-HT2C receptor agonist (with pKi values of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). That assignment has been questioned, however, supported by evidence from coadministration of Ro 60-0175 and SB 242084, a selective 5-HT2C antagonist.1