PMEG hydrate

• Catalog No.: M2199
• M. F.: C8H14N5O6P
• M. W.: 307.200421
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: {[2-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)ethoxy]methyl}phosphonic acid hydrate
• IUPAC Traditional name: [2-(2-amino-6-oxo-1H-purin-9-yl)ethoxy]methylphosphonic acid hydrate
• Synonyms: 9-[2-(Phosphonomethoxy)ethyl]guanine hydrate

DATABASE IDS

• MDL Number: MFCD19443863

PROPERTIES

• Empirical Formula (Hill Notation): C8H12N5O5P · xH2O
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: ≥5 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H300
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P264-P301 + P310
• Risk Statements: 25
• Safety Statements: 45
• Storage Condition: desiccated
• Storage Temperature: 2-8°C

DETAILS

Description (English)

Biochem/physiol Actions
The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.

Description (简体中文)

Biochem/physiol Actions
The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.