ITX3

• Catalog No.: I1411
• CAS Number: 347323-96-0
• M. F.: C22H25N3OS
• M. W.: 379.5184
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylidene]-5-thia-2,7-diazatricyclo[6.4.0.0^2,^6]dodecan-3-one
• IUPAC Traditional name: 4-[(2,5-dimethyl-1-phenylpyrrol-3-yl)methylidene]-5-thia-2,7-diazatricyclo[6.4.0.0^2,^6]dodecan-3-one
• Synonyms: 2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-thiazolo[3,2-a]benzimidazol-3(2H)-one

DATABASE IDS

• MDL Number: MFCD02629172
• CAS Number: 347323-96-0

PROPERTIES

• Empirical Formula (Hill Notation): C22H17N3OS
• Purity: ≥98% (HPLC)
• Apperance: powder
• Solubility: DMSO: ≥4 mg/mL
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.

Description (简体中文)

Biochem/physiol Actions
ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.