SB-271046A

• Catalog No.: S5326
• CAS Number: 209481-24-3
• M. F.: C20H23Cl2N3O3S2
• M. W.: 488.45092
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride
• IUPAC Traditional name: 5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride
• Synonyms: 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzo-thiophenesulfonamide hydrochloride

DATABASE IDS

• MDL Number: MFCD10565914
• CAS Number: 209481-24-3

PROPERTIES

• Empirical Formula (Hill Notation): C20H22ClN3O3S2 · HCl
• Purity: ≥98% (HPLC)
• Apperance: powder
• Solubility: DMSO: >20 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: nwg

DETAILS

Description (English)

Biochem/physiol Actions
The first potent and selective 5-HT6 antagonist. Training in cognitive tasks, as well as administration SB-271046, induces an increase in pERK1/2 and pCREB1 levels, while CREB2 levels are significantly reduced; cognition-enhancing properties of SB-271046 are attributed to the effect on pERK1/2, not pCREB1/2.1 SB-271046 reverses MK-801-induced, but not scopolamine-induced, learning impairments. However, with coadministration of galanthamine, both types of learning impairments were ameliorated.2

Description (简体中文)

Biochem/physiol Actions
The first potent and selective 5-HT6 antagonist. Training in cognitive tasks, as well as administration SB-271046, induces an increase in pERK1/2 and pCREB1 levels, while CREB2 levels are significantly reduced; cognition-enhancing properties of SB-271046 are attributed to the effect on pERK1/2, not pCREB1/2.1 SB-271046 reverses MK-801-induced, but not scopolamine-induced, learning impairments. However, with coadministration of galanthamine, both types of learning impairments were ameliorated.2