YS-49 monohydrate

• Catalog No.: Y1521
• CAS Number: 132836-42-1(anhydrous)
• M. F.: C20H22BrNO3
• M. W.: 404.29758
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrate hydrobromide
• IUPAC Traditional name: 1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrate hydrobromide
• Synonyms: 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate

DATABASE IDS

• CAS Number: 132836-42-1(anhydrous)
• MDL Number: MFCD16875442

PROPERTIES

• Empirical Formula (Hill Notation): C20H19NO2 · HBr · H2O
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: H2O: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• European Hazard Symbols: Nature polluting (N)
• Risk Statements: 22-50
• Safety Statements: 61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
YS-49 protects cells from oxidant injury; anti-inflammatory agent; activator of PI3K/Akt signaling. YS-49, an analog of higenamine, induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury. The compound was reported to inhibit Ang II-stimulated VSMC proliferation through HO-1 production, which inhibits both the JNK pathway and ROS production. A study (JPET) reported that CKD712 (S-YS-49) confer cardiac protection and anti-inflammatory via activation of the PI3K signal pathway. These effects were antagonized by a PI3K inhibitor, wortmannin.

Description (简体中文)

Biochem/physiol Actions
YS-49 protects cells from oxidant injury; anti-inflammatory agent; activator of PI3K/Akt signaling. YS-49, an analog of higenamine, induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury. The compound was reported to inhibit Ang II-stimulated VSMC proliferation through HO-1 production, which inhibits both the JNK pathway and ROS production. A study (JPET) reported that CKD712 (S-YS-49) confer cardiac protection and anti-inflammatory via activation of the PI3K signal pathway. These effects were antagonized by a PI3K inhibitor, wortmannin.