PHPS1 sodium salt hydrate

• Catalog No.: P0039
• CAS Number: 314291-83-3(freeacid)
• M. F.: C21H16N5NaO7S
• M. W.: 505.43581
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: sodium 4-{2-[3-(4-nitrophenyl)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}benzene-1-sulfonate hydrate
• IUPAC Traditional name: sodium 4-{2-[3-(4-nitrophenyl)-5-oxo-1-phenylpyrazol-4-ylidene]hydrazin-1-yl}benzenesulfonate hydrate
• Synonyms: 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate

DATABASE IDS

• CAS Number: 314291-83-3(freeacid)

PROPERTIES

• Empirical Formula (Hill Notation): C21H15N5O6S · xNa+ · yH2O
• Purity: ≥98% (HPLC)
• Apperance: red solid
• Solubility: DMSO: soluble10 mg/mL, clear (warmed)
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Shp-2 is a Src Homology-2 (SH2) containing phosphatase that regulates growth factor signalling. The enzyme is expressed ubiquitously in mammalian tissues and plays essential roles in development. It is also implicated in various pathological states. PHPS1 is a selective inhibitor of Shp-2 and blocks Shp-2 dependent downstream signalling.

Description (简体中文)

Biochem/physiol Actions
Shp-2 is a Src Homology-2 (SH2) containing phosphatase that regulates growth factor signalling. The enzyme is expressed ubiquitously in mammalian tissues and plays essential roles in development. It is also implicated in various pathological states. PHPS1 is a selective inhibitor of Shp-2 and blocks Shp-2 dependent downstream signalling.