L-365260

• Catalog No.: L4795
• CAS Number: 118101-09-0
• M. F.: C24H24N4O
• M. W.: 384.47356
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 1-[(3R)-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea
• IUPAC Traditional name: 1-[(3R)-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea
• Synonyms: N-[(3R)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N′-(3-methylphenyl)-urea

DATABASE IDS

• CAS Number: 118101-09-0

PROPERTIES

• Empirical Formula (Hill Notation): C24H22N4O2
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H400
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P301 + P310
• Risk Statements: 25-50/53
• Safety Statements: 45-60-61
• Storage Condition: desiccated
• Storage Temperature: -20°C

DETAILS

Description (English)

Biochem/physiol Actions
L-365260 is a CCK2 selective antagonist. Enhances amphetamine-induced stimulation of locomotor activity in rats (a model of drug abuse), inhibits thyroid carcinoma (TT)-cell proliferation (potential therapeutic implication for cancer treatment); bilateral injection into the medulla reverses both tactile allodynia and thermal hyperalgesia.

Description (简体中文)

Biochem/physiol Actions
L-365260 is a CCK2 selective antagonist. Enhances amphetamine-induced stimulation of locomotor activity in rats (a model of drug abuse), inhibits thyroid carcinoma (TT)-cell proliferation (potential therapeutic implication for cancer treatment); bilateral injection into the medulla reverses both tactile allodynia and thermal hyperalgesia.