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Nitazoxanide

Catalog No. N0290 Name Sigma Aldrich
CAS Number 55981-09-4 Website http://www.sigmaaldrich.com
M. F. C12H9N3O5S Telephone 1-800-521-8956
M. W. 307.28196 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 389

SYNONYMS

IUPAC name
2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
IUPAC Traditional name
nitazoxanide
Synonyms
NTZ; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide

DATABASE IDS

CAS Number 55981-09-4
MDL Number MFCD00416599
EC Number 259-931-8

PROPERTIES

Empirical Formula (Hill Notation) C12H9N3O5S
Purity ≥98% (HPLC)
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H315-H319-H335
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 22-36/37/38
Safety Statements 26-36
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria. FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.
Description (简体中文)
Biochem/physiol Actions
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria. FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.

REFERENCES