Nitazoxanide

• Catalog No.: N0290
• CAS Number: 55981-09-4
• M. F.: C12H9N3O5S
• M. W.: 307.28196
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
• IUPAC Traditional name: nitazoxanide
• Synonyms: NTZ; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide

DATABASE IDS

• CAS Number: 55981-09-4
• MDL Number: MFCD00416599
• EC Number: 259-931-8

PROPERTIES

• Empirical Formula (Hill Notation): C12H9N3O5S
• Purity: ≥98% (HPLC)
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria. FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.

Description (简体中文)

Biochem/physiol Actions
Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria. FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.