6, 2′, 4′-trimethoxyflavone

• Catalog No.: T4080
• CAS Number: 720675-90-1
• M. F.: C18H16O5
• M. W.: 312.31664
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 2-(2,4-dimethoxyphenyl)-6-methoxy-4H-chromen-4-one
• IUPAC Traditional name: 2-(2,4-dimethoxyphenyl)-6-methoxychromen-4-one
• Synonyms: 2-(2,4-Dimethoxyphenyl)-2,3-dihydro-6-methoxy-4H-1-benzopyran-4-one; TMF; Trimethoxyflavone

DATABASE IDS

• MDL Number: MFCD03412381
• CAS Number: 720675-90-1

PROPERTIES

• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• Safety Statements: 45
• Storage Condition: desiccated
• Storage Condition: protect from light
• Storage Temperature: room temp
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3
• GHS Signal Word: Danger
• Empirical Formula (Hill Notation): C18H16O5
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: >5 mg/mL

DETAILS

Description (English)

Biochem/physiol Actions
6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function.

Description (简体中文)

Biochem/physiol Actions
6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function.