Zerumbone

• Catalog No.: Z3902
• CAS Number: 471-05-6
• M. F.: C15H22O
• M. W.: 218.33458
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one
• IUPAC Traditional name: 2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one
• Synonyms: Zerumbone (6CI,7CI); (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one

DATABASE IDS

• MDL Number: MFCD03700769
• CAS Number: 471-05-6

PROPERTIES

• Empirical Formula (Hill Notation): C15H22O
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: ≥10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H317-H400
• European Hazard Symbols: Irritant (Xi)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P280
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 43-50
• Safety Statements: 36/37-60-61
• Storage Temperature: 2-8°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Zerumbone is a TRAIL-induced apoptosis potentiator. It potentiates TRAIL-induced apoptosis through the up-regulation of DR4 and DR5 expression and the down-regulation of cFLIP. Zerumbone has very little or no cytotoxic effect on the normal human endothelial cells and dermal fibroblasts. Zerumbone is a sesquiterpene isolated from in Zingiber zerumbet Smith (wild ginger).

Description (简体中文)

Biochem/physiol Actions
Zerumbone is a TRAIL-induced apoptosis potentiator. It potentiates TRAIL-induced apoptosis through the up-regulation of DR4 and DR5 expression and the down-regulation of cFLIP. Zerumbone has very little or no cytotoxic effect on the normal human endothelial cells and dermal fibroblasts. Zerumbone is a sesquiterpene isolated from in Zingiber zerumbet Smith (wild ginger).