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N-Methyl-L-tyrosine_Molecular_structure_CAS_537-49-5)
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N-Methyl-L-tyrosine

Catalog No. 04632 Name Sigma Aldrich
CAS Number 537-49-5 Website http://www.sigmaaldrich.com
M. F. C10H13NO3 Telephone 1-800-521-8956
M. W. 195.21512 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154616

SYNONYMS

IUPAC name
(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid
IUPAC Traditional name
L-tyrosine, N-methyl-
Synonyms
Surinamine
(S)-3-(4-Hydroxyphenyl)-2-(methylamino)propionic acid
N-Me-Tyr-OH

DATABASE IDS

MDL Number MFCD00238322
CAS Number 537-49-5
EC Number 208-670-8
Beilstein Number 2646795

PROPERTIES

Compostion carbon, 60.7-62.3%
Compostion nitrogen, 6.9-7.5%
Empirical Formula (Hill Notation) C10H13NO3
Purity ≥98% (HPLC)
Optical Rotation [α]/D +16.0±1.0°, c = 1 in 1 M HCl
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
GHS Precautionary statements P305 + P351 + P338
Risk Statements 36-38
Safety Statements 26
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease2, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.
Application
N-Methyl-L-tyrosine was used in experiments as a control group to show that methylation of the imino group in N-p-phenylpropionyl-L-tyrosine eliminates its inhibitory effect on the firing of the giant neurone of the giant African snail. 1
Description (简体中文)
Biochem/physiol Actions
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease2, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.
Application
N-Methyl-L-tyrosine was used in experiments as a control group to show that methylation of the imino group in N-p-phenylpropionyl-L-tyrosine eliminates its inhibitory effect on the firing of the giant neurone of the giant African snail. 1

REFERENCES