VU 590 dihydrochloride hydrate

• Catalog No.: V4265
• M. F.: C24H36Cl2N4O8
• M. W.: 579.47064
• Purity: ≥ (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 7,13-bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane hydrate dihydrochloride
• IUPAC Traditional name: 7,13-bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane hydrate dihydrochloride

DATABASE IDS

• MDL Number: MFCD16875439

PROPERTIES

• Empirical Formula (Hill Notation): C24H32N4O7·2HCl · xH2O
• Purity: ≥ (HPLC)
• Apperance: solid
• Solubility: deionized water: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
VU590 inhibits ROMK at sub-micromolar affinity (294 nM) and Kir7.1 at low micromolar affinity, but it does not inhibit Kir2.1 or Kir4.1. VU590 appears to act by blocking the ion permeation pathway of the channel.

Description (简体中文)

Biochem/physiol Actions
VU590 inhibits ROMK at sub-micromolar affinity (294 nM) and Kir7.1 at low micromolar affinity, but it does not inhibit Kir2.1 or Kir4.1. VU590 appears to act by blocking the ion permeation pathway of the channel.