Osthole

• Catalog No.: O9265
• CAS Number: 484-12-8
• M. F.: C15H16O3
• M. W.: 244.28574
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
• IUPAC Traditional name: osthole
• Synonyms: 7-Methoxy-8-(3-methyl-2-butenyl)coumarin; 7-Methoxy-8-isopentenylcoumarin; Osthol

DATABASE IDS

• CAS Number: 484-12-8
• MDL Number: MFCD00076049

PROPERTIES

• Empirical Formula (Hill Notation): C15H16O3
• Purity: ≥95% (HPLC)
• Apperance: white powder
• Solubility: methanol: soluble10 mg/mL, clear, colorless
• RTECS: GN7700000
• Storage Temperature: room temp
• German water hazard class: 1

DETAILS

Description (简体中文)

Biochem/physiol Actions
Active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Dramatically decreased lipid accumulation in a quail model.1 Its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of osthole as a therapeutic agent for the treatment of neurodegenerative disorders.2 Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.3
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. O9265.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Description (English)

Biochem/physiol Actions
Active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Dramatically decreased lipid accumulation in a quail model.1 Its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of osthole as a therapeutic agent for the treatment of neurodegenerative disorders.2 Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.3
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. O9265.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.