Fasentin

• Catalog No.: F5557
• CAS Number: 392721-37-8
• M. F.: C11H9ClF3NO2
• M. W.: 279.6428696
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
• IUPAC Traditional name: N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
• Synonyms: N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

DATABASE IDS

• CAS Number: 392721-37-8
• MDL Number: MFCD01001285

PROPERTIES

• Empirical Formula (Hill Notation): C11H9ClF3NO2
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. Fasentin is a novel inhibitor of glucose uptake that sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1.

Description (简体中文)

Biochem/physiol Actions
Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. Fasentin is a novel inhibitor of glucose uptake that sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1.