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CP-471474

Catalog No. PZ0137 Name Sigma Aldrich
CAS Number 210755-45-6 Website http://www.sigmaaldrich.com
M. F. C16H17FN2O5S Telephone 1-800-521-8956
M. W. 368.3799832 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154609

SYNONYMS

IUPAC name
2-[4-(4-fluorophenoxy)benzenesulfonamido]-N-hydroxy-2-methylpropanamide
IUPAC Traditional name
2-[4-(4-fluorophenoxy)benzenesulfonamido]-N-hydroxy-2-methylpropanamide
Synonyms
PF-1626077
2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide

DATABASE IDS

CAS Number 210755-45-6
MDL Number MFCD16618408

PROPERTIES

Empirical Formula (Hill Notation) C16H17FN2O5S
Purity ≥98% (HPLC)
Apperance white to off-white powder
Solubility DMSO: ≥20 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Risk Statements 22
Storage Temperature room temp
German water hazard class 1

DETAILS

Description (English)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC50 efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC50 > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.
Description (简体中文)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC50 efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC50 > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.

REFERENCES