SKA-31

• Catalog No.: S5576
• CAS Number: 40172-65-4
• M. F.: C11H8N2S
• M. W.: 200.25962
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: naphtho[1,2-d][1,3]thiazol-2-amine
• IUPAC Traditional name: naphtho[1,2-d][1,3]thiazol-2-amine
• Synonyms: Naphtho[1,2-d]thiazol-2-ylamine

DATABASE IDS

• MDL Number: MFCD00051329
• CAS Number: 40172-65-4

PROPERTIES

• Empirical Formula (Hill Notation): C11H8N2S
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: ≥30 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H319
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 22-36
• Safety Statements: 26
• Storage Temperature: -20°C

DETAILS

Description (English)

Biochem/physiol Actions
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice,1 suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.

Description (简体中文)

Biochem/physiol Actions
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice,1 suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.