Taurolidine

• Catalog No.: T7329
• CAS Number: 19388-87-5
• M. F.: C7H16N4O4S2
• M. W.: 284.35634
• Purity: >97% (NMR)
• Storage: protect from light

SYNONYMS

• Title: 滔罗林
• IUPAC name: 4-[(1,1-dioxo-1λ^6,2,4-thiadiazinan-4-yl)methyl]-1λ^6,2,4-thiadiazinane-1,1-dione
• IUPAC Traditional name: taurolidine
• Synonyms: 4,4′-Methylenebis(tetrahydro-1,2,4-sulfadiazine 1,1-dioxide); 4,4′-亚甲双[四氢-2H-1,2,4-噻二嗪]1,1,1′,1′-四氧化物; 牛磺罗定; Taurolin; 4,4′-亚甲基双(四氢-1,2,4-磺胺嘧啶 1,1-二氧化物); Tauroline

DATABASE IDS

• CAS Number: 19388-87-5
• MDL Number: MFCD00865076
• EC Number: 243-016-5

PROPERTIES

• Empirical Formula (Hill Notation): C7H16N4O4S2
• Purity: >97% (NMR)
• Apperance: white to off-white powder
• Solubility: DMSO: >20 mg/mL
• Storage Condition: protect from light
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Taurolidine is a broad spectrum antibiotic with antineoplastic activity, which induces apoptosis and decreases tumor cell proliferation. Taurolidine has been used with TNF-related-apoptosis-inducing ligand (TRAIL) to characterize synergistic responses in many apoptosis related signaling-proteins. Tauroline is also being used as a tool to study the various mechanisms of apoptosis and necrosis.

Description (简体中文)

Biochem/physiol Actions
滔罗林是一种具有抗肿瘤活性的广谱抗生素，可以引起细胞凋亡并减少肿瘤细胞增殖。滔罗林已与肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 搭配使用以描述许多细胞凋亡相关信号蛋白的协同反应。由于无毒的滔罗林可以降低重组人肿瘤坏死因子相关凋亡诱导配体 (rhTRAIL) 的毒性和剂量，因此滔罗林与 rhTRAIL 联用的治疗方式可以为癌症治疗提供新的选择。滔罗林也被用作研究细胞凋亡和坏死的多种机理的工具。