SYUIQ-5

• Catalog No.: S5826
• CAS Number: 188630-47-9
• M. F.: C20H22N4
• M. W.: 318.41548
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: [3-({10H-indolo[3,2-b]quinolin-11-yl}amino)propyl]dimethylamine
• IUPAC Traditional name: (3-{10H-indolo[3,2-b]quinolin-11-ylamino}propyl)dimethylamine
• Synonyms: N′-(10H-Indolo [3,2-b]quinolin-11-yl)-N, N-dimethyl-propane-1,3-diamine

DATABASE IDS

• CAS Number: 188630-47-9
• MDL Number: MFCD17215940

PROPERTIES

• Empirical Formula (Hill Notation): C20H22N4
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H400
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273
• Risk Statements: 50
• Safety Statements: 61
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.

Description (简体中文)

Biochem/physiol Actions
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.