10074-G5

• Catalog No.: G3798
• CAS Number: 413611-93-5
• M. F.: C18H12N4O3
• M. W.: 332.31288
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 7-nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine
• IUPAC Traditional name: 7-nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine
• Synonyms: N-[1,1′-Biphenyl-2-yl]-7-nitro-2,1,3-Benzoxadiazol-4-amine; N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-amine; Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine

DATABASE IDS

• MDL Number: MFCD00576774
• CAS Number: 413611-93-5

PROPERTIES

• Empirical Formula (Hill Notation): C18H12N4O3
• Purity: ≥98% (HPLC)
• Apperance: red powder
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P261-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-36/37/38
• Safety Statements: 26-45
• Storage Temperature: room temp
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.

Description (简体中文)

Biochem/physiol Actions
10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.