T3MG

• Catalog No.: T2455
• CAS Number: 63088-04-0
• M. F.: C6H11NO4
• M. W.: 161.15584
• Purity: (single spot, TLC)

SYNONYMS

• IUPAC name: (2R,3S)-2-amino-3-methylpentanedioic acid
• IUPAC Traditional name: (3r)-3-methyl-L-glutamic acid
• Synonyms: 3MG; (±)-threo-3-Methylglutamic acid; threo-3-Methylglutamate

DATABASE IDS

• CAS Number: 63088-04-0
• MDL Number: MFCD09836097

PROPERTIES

• Empirical Formula (Hill Notation): C6H11NO4
• Purity: (single spot, TLC)
• Apperance: white to off-white powder
• Solubility: H2O: >1.5 mg/dL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

Description (简体中文)

Biochem/physiol Actions
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.