Pyronaridine tetraphosphate

• Catalog No.: P0049
• CAS Number: 76748-86-2
• M. F.: C29H44ClN5O18P4
• M. W.: 910.030404
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: 4-({7-chloro-2-methoxybenzo[b]1,5-naphthyridin-10-yl}amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol; tetrakis(phosphoric acid)
• IUPAC Traditional name: tetrakis(phosphoric acid); pyronaridine
• Synonyms: 2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate

DATABASE IDS

• CAS Number: 76748-86-2
• MDL Number: MFCD05863545

PROPERTIES

• Empirical Formula (Hill Notation): C29H32ClN5O2·4H3PO4
• Purity: ≥95% (HPLC)
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H318-H361-H413
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280-P301 + P310-P305 + P351 + P338
• Risk Statements: 63-22-41
• RTECS: SK4920000
• Safety Statements: 26-36/37-39
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Pyronaridine blocks β-hematin formation in vitro3 and has inhibitory activity toward P-glycoprotein mediated drug resistance.4 Antimalarial used on conjunction with artensunate.5
Pyronaridine has antimalarial activity. It is antagonistic against naphthoquine and dihydroartemisinin2. Pyronaridine blocks β-hematin formation in vitro3 and has inhibitory activity toward P-glycoprotein mediated drug resistance.4
Application
Pyronaridine, an acridine derivative, is an antimalarial drug. It is used in China as a treatment for drug-resistant falciparum malaria1. It′s in vitro activities have been studies against Plasmodium falciparum in Cameroon2.

Description (简体中文)

Biochem/physiol Actions
Pyronaridine blocks β-hematin formation in vitro3 and has inhibitory activity toward P-glycoprotein mediated drug resistance.4 Antimalarial used on conjunction with artensunate.5
Pyronaridine has antimalarial activity. It is antagonistic against naphthoquine and dihydroartemisinin2. Pyronaridine blocks β-hematin formation in vitro3 and has inhibitory activity toward P-glycoprotein mediated drug resistance.4
Application
Pyronaridine, an acridine derivative, is an antimalarial drug. It is used in China as a treatment for drug-resistant falciparum malaria1. It′s in vitro activities have been studies against Plasmodium falciparum in Cameroon2.