Lamivudine

• Catalog No.: L1295
• CAS Number: 134678-17-4
• M. F.: C8H11N3O3S
• M. W.: 229.25624
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
• IUPAC Traditional name: lamivudine
• Synonyms: 3TC; 2′,3′-Dideoxy-3′-thiacytidine; Zeffix; Epivir-HBV; Epivir; Heptovir

DATABASE IDS

• CAS Number: 134678-17-4
• MDL Number: MFCD00869739

PROPERTIES

• Empirical Formula (Hill Notation): C8H11N3O3S
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.

Description (简体中文)

Biochem/physiol Actions
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.