Calcipotriol hydrate

• Catalog No.: C4369
• CAS Number: 112965-21-6(anhydrous)
• M. F.: C27H42O4
• M. W.: 430.61998
• Purity: ≥99% (HPLC)

SYNONYMS

• IUPAC name: (1R,3S)-5-{2-[(1R,3aS,7aR)-1-[(2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol hydrate
• IUPAC Traditional name: (1R,3S)-5-{2-[(1R,3aS,7aR)-1-[(2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-hexahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol hydrate
• Synonyms: Calcipotriene; (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol

DATABASE IDS

• MDL Number: MFCD10567086
• CAS Number: 112965-21-6(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C27H40O3 · xH2O
• Purity: ≥99% (HPLC)
• Apperance: solid
• Solubility: DMSO: ≥24 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H310-H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P302 + P350-P305 + P351 + P338-P310
• Risk Statements: 36/37/38
• RTECS: VS2830000
• Safety Statements: 26
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.

Description (简体中文)

Biochem/physiol Actions
Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.