Src Inhibitor-1

• Catalog No.: S2075
• CAS Number: 179248-59-0
• M. F.: C22H19N3O3
• M. W.: 373.40456
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
• IUPAC Traditional name: 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
• Synonyms: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine; Src-l1; SKI-1; 4-(4′-Phenoxyanilino)-6,7-dimethoxyquinazoline

DATABASE IDS

• MDL Number: MFCD01815300
• CAS Number: 179248-59-0

PROPERTIES

• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335-H413
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P261-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3
• Empirical Formula (Hill Notation): C22H19N3O3
• Purity: ≥98% (HPLC)
• Apperance: white powder
• Solubility: DMSO: >10 mg/mL

DETAILS

Description (English)

Biochem/physiol Actions
Src Inhibitor-1 is a potent, competitve dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the "gold standards" for Src kinase inhibition. It has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. Src Inhibitor-1 is a selective, competitive inhibitor of Src family of tyrosine kinases (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Src Inhibitor-1 Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC50 = 0.32 μM and 30 μM, respectively).

Description (简体中文)

Biochem/physiol Actions
Src Inhibitor-1 is a potent, competitve dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the "gold standards" for Src kinase inhibition. It has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. Src Inhibitor-1 is a selective, competitive inhibitor of Src family of tyrosine kinases (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Src Inhibitor-1 Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC50 = 0.32 μM and 30 μM, respectively).