CPPHA

• Catalog No.: C2247
• CAS Number: 693288-97-0
• M. F.: C22H15ClN2O4
• M. W.: 406.8185
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: N-{4-chloro-2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
• IUPAC Traditional name: N-{4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
• Synonyms: N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide; N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide

DATABASE IDS

• MDL Number: MFCD12912405
• CAS Number: 693288-97-0

PROPERTIES

• Empirical Formula (Hill Notation): C22H15ClN2O4
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H410
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P501
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 50/53
• Safety Statements: 60-61
• Storage Condition: desiccated
• Storage Temperature: -20°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.

Description (简体中文)

Biochem/physiol Actions
CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.