Razoxane

• Catalog No.: R8657
• CAS Number: 21416-67-1
• M. F.: C11H16N4O4
• M. W.: 268.26914
• Purity: >98% (HPLC)

SYNONYMS

• IUPAC name: 4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
• IUPAC Traditional name: razoxane
• Synonyms: Troxozone; ICI 59118; (±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; Tepirone; ICRF 159; (±)-1,2-Bis(3,5-dioxopiperazinyl)propane; 1,2-Bis(3,5-dioxo-1-piperazinyl)propane; 4,4′-Propylenebis(2,6-piperazinedione); NSC 129943; Razoxin

DATABASE IDS

• MDL Number: MFCD00430424
• CAS Number: 21416-67-1
• EC Number: 244-379-2

PROPERTIES

• Empirical Formula (Hill Notation): C11H16N4O4
• Purity: >98% (HPLC)
• Apperance: solid
• Solubility: DMSO: soluble40 mg/mL
• RTECS: TL6389900
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

Description (简体中文)

Biochem/physiol Actions
Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.