Home > Compound List > Product Information
Razoxane_Molecular_structure_CAS_21416-67-1)
Click picture or here to close

Razoxane

Catalog No. R8657 Name Sigma Aldrich
CAS Number 21416-67-1 Website http://www.sigmaaldrich.com
M. F. C11H16N4O4 Telephone 1-800-521-8956
M. W. 268.26914 Fax
Purity >98% (HPLC) Email
Storage Chembase ID: 70615

SYNONYMS

IUPAC name
4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
IUPAC Traditional name
razoxane
Synonyms
Troxozone
ICI 59118
(±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
Tepirone
ICRF 159
(±)-1,2-Bis(3,5-dioxopiperazinyl)propane
1,2-Bis(3,5-dioxo-1-piperazinyl)propane
4,4′-Propylenebis(2,6-piperazinedione)
NSC 129943
Razoxin

DATABASE IDS

MDL Number MFCD00430424
CAS Number 21416-67-1
EC Number 244-379-2

PROPERTIES

Empirical Formula (Hill Notation) C11H16N4O4
Purity >98% (HPLC)
Apperance solid
Solubility DMSO: soluble40 mg/mL
MSDS Link Download
RTECS TL6389900
Storage Temperature room temp
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.
Description (简体中文)
Biochem/physiol Actions
Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

REFERENCES