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S-2E

Catalog No. S6445 Name Sigma Aldrich
CAS Number 155730-92-0 Website http://www.sigmaaldrich.com
M. F. C22H25NO4 Telephone 1-800-521-8956
M. W. 367.4382 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154538

SYNONYMS

IUPAC name
4-{[(3S)-1-(4-tert-butylphenyl)-5-oxopyrrolidin-3-yl]methoxy}benzoic acid
IUPAC Traditional name
4-{[(3S)-1-(4-tert-butylphenyl)-5-oxopyrrolidin-3-yl]methoxy}benzoic acid
Synonyms
(S)-(+)-4-[1-(4-tert-Butylphenyl)-2-oxo-pyrrolidin-4-yl]methoxybenzoic acid

DATABASE IDS

PubChem SID 24724620
MDL Number MFCD06407742
CAS Number 155730-92-0

PROPERTIES

Empirical Formula (Hill Notation) C22H25NO4
Purity ≥98% (HPLC)
Apperance white powder
Solubility DMSO: soluble11 mg/mL
Solubility H2O: insoluble
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Packaging
Shipped ambient under nitrogen.
Biochem/physiol Actions
HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibited the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at K(i)=18.11 microM and K(i)=69.2 microM, respectively.
Description (简体中文)
包装
Shipped ambient under nitrogen.
Biochem/physiol Actions
HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibited the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at K(i)=18.11 microM and K(i)=69.2 microM, respectively.

REFERENCES