S-PMH

• Catalog No.: S0826
• M. F.: C12H12N2O2S
• M. W.: 248.30088
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 5-{[4-(ethylsulfanyl)phenyl]methylidene}imidazolidine-2,4-dione
• IUPAC Traditional name: 5-{[4-(ethylsulfanyl)phenyl]methylidene}imidazolidine-2,4-dione
• Synonyms: (Z)-5-(4-(ethylthio)benzylidene)-hydantoin; 5-(4-Ethylsulfanylbenzylidene)imidazolidine-2,4-dione; (Z)-5-[4-(Ethylthio)benzylidene]imidazolidine-2,4-dione

DATABASE IDS

• MDL Number: MFCD12912441

PROPERTIES

• Empirical Formula (Hill Notation): C12H12N2O2S
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: >20 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
S-PMH augments cell-cell adhesion by enhancing tight and adherens junctions (TJ and AJ) and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes. Calcitonin and its receptor are expressed in prostate cell cancers and plays a pivotal role in metastasis and tumorgenesis. It appears that CT promotes prostate cancer metastasis by reducing cell-cell adhesion through the disassembly of tight and adherens junctions and activation of B-catenin signaling. S-PMH apparently blocks CT-stimulated alphavbeta3 activity (a key factor in bone metastasis). In a nude mice model I.p. administered S-PMH and its S-ethyl derivative decreased orthotopic tumor growth and inhibited the formation of tumor micrometastases in distant organs. S-PMH is relatively nontoxic in a cell proliferation assay.

Description (简体中文)

Biochem/physiol Actions
S-PMH augments cell-cell adhesion by enhancing tight and adherens junctions (TJ and AJ) and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes. Calcitonin and its receptor are expressed in prostate cell cancers and plays a pivotal role in metastasis and tumorgenesis. It appears that CT promotes prostate cancer metastasis by reducing cell-cell adhesion through the disassembly of tight and adherens junctions and activation of B-catenin signaling. S-PMH apparently blocks CT-stimulated alphavbeta3 activity (a key factor in bone metastasis). In a nude mice model I.p. administered S-PMH and its S-ethyl derivative decreased orthotopic tumor growth and inhibited the formation of tumor micrometastases in distant organs. S-PMH is relatively nontoxic in a cell proliferation assay.