N-Arachidonylmaleimide

• Catalog No.: A2984
• CAS Number: 876305-42-9
• M. F.: C24H35NO2
• M. W.: 369.5402
• Purity: ≥98% (HPLC)
• Storage: under inert gas

SYNONYMS

• IUPAC name: 1-(icosa-5,8,11,14-tetraen-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
• IUPAC Traditional name: 1-(icosa-5,8,11,14-tetraen-1-yl)pyrrole-2,5-dione

DATABASE IDS

• CAS Number: 876305-42-9
• MDL Number: MFCD11521506

PROPERTIES

• Empirical Formula (Hill Notation): C24H35NO2
• Purity: ≥98% (HPLC)
• Apperance: solid
• GHS Signal Word: Warning
• GHS Hazard statements: H317
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P280
• Risk Statements: 43
• Safety Statements: 36/37
• Storage Condition: under inert gas
• Storage Temperature: -20°C
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
N-Arachidonylmaleidmide, NAM, is a potent irreversible inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes.

Description (简体中文)

Biochem/physiol Actions
N-Arachidonylmaleidmide, NAM, is a potent irreversible inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes.