Nicorandil

• Catalog No.: N3539
• CAS Number: 65141-46-0
• M. F.: C8H9N3O4
• M. W.: 211.17476
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-(pyridin-3-ylformamido)ethyl nitrate
• IUPAC Traditional name: nicorandil
• Synonyms: Zynicor; 2-(Pyridine-3-carbonylamino)ethyl nitrate; N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide; 2-Nicotinamidoethyl nitrate; SG-75; Sigmart; Ikorel

DATABASE IDS

• CAS Number: 65141-46-0
• MDL Number: MFCD00186520
• EC Number: 265-514-1

PROPERTIES

• Empirical Formula (Hill Notation): C8H9N3O4
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H318
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280-P305 + P351 + P338
• Risk Statements: 22-41
• RTECS: US4667600
• Safety Statements: 26-39
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

Description (简体中文)

Biochem/physiol Actions
Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.