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Nicorandil

Catalog No. N3539 Name Sigma Aldrich
CAS Number 65141-46-0 Website http://www.sigmaaldrich.com
M. F. C8H9N3O4 Telephone 1-800-521-8956
M. W. 211.17476 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 72829

SYNONYMS

IUPAC name
2-(pyridin-3-ylformamido)ethyl nitrate
IUPAC Traditional name
nicorandil
Synonyms
Zynicor
2-(Pyridine-3-carbonylamino)ethyl nitrate
N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
2-Nicotinamidoethyl nitrate
SG-75
Sigmart
Ikorel

DATABASE IDS

CAS Number 65141-46-0
MDL Number MFCD00186520
EC Number 265-514-1

PROPERTIES

Empirical Formula (Hill Notation) C8H9N3O4
Purity ≥98% (HPLC)
Apperance white to off-white powder
Solubility DMSO: >10 mg/mL
GHS Pictograms GHS05
GHS Pictograms GHS07
GHS Signal Word Danger
GHS Hazard statements H302-H318
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P280-P305 + P351 + P338
Risk Statements 22-41
RTECS US4667600
Safety Statements 26-39
Storage Temperature room temp
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.
Description (简体中文)
Biochem/physiol Actions
Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.

REFERENCES