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GW9508

Catalog No. G9797 Name Sigma Aldrich
CAS Number 885101-89-3 Website http://www.sigmaaldrich.com
M. F. C22H21NO3 Telephone 1-800-521-8956
M. W. 347.40704 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154499

SYNONYMS

IUPAC name
3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid
IUPAC Traditional name
3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid
Synonyms
4-(3-Phenoxybenzylamino)phenylpropionic acid

DATABASE IDS

CAS Number 885101-89-3
MDL Number MFCD09753282

PROPERTIES

Empirical Formula (Hill Notation) C22H21NO3
Purity ≥98% (HPLC)
Apperance white powder
Solubility DMSO: >20 mg/mL
GHS Pictograms GHS05
GHS Pictograms GHS07
GHS Pictograms GHS09
GHS Signal Word Danger
GHS Hazard statements H302-H315-H318-H335-H410
European Hazard Symbols Harmful Harmful (Xn)
European Hazard Symbols Nature polluting Nature polluting (N)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements P261-P273-P280-P305 + P351 + P338-P501
RID/ADR UN 3077 9/PG 3
Risk Statements 22-37/38-41-50/53
Safety Statements 26-39-60-61
Storage Temperature 2-8°C
Hazard Class 9
UN Number 3077
Packing Group 3
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca2+ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.
Description (简体中文)
Biochem/physiol Actions
GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca2+ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.

REFERENCES