1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

• Catalog No.: 76548
• CAS Number: 4004-05-1
• M. F.: C41H78NO8P
• M. W.: 744.033681
• Purity: ≥97.0% (TLC)

SYNONYMS

• Title: 1,2-二油酰-sn-甘油-3-磷酸乙醇胺
• IUPAC name: (2-aminoethoxy)[(2R)-2,3-bis(octadec-9-enoyloxy)propoxy]phosphinic acid
• IUPAC Traditional name: 2-aminoethoxy(2R)-2,3-bis(octadec-9-enoyloxy)propoxyphosphinic acid
• Synonyms: 3-sn-Phosphatidylethanolamine, 1,2-dideoyl; (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester; DOPE; Dioleoyl phosphatidylethanolamine; 1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; L-β,γ-Dioleoyl-α-cephalin; PE(18:1(9Z)/18:1(9Z))

DATABASE IDS

• Beilstein Number: 1718431
• CAS Number: 4004-05-1
• MDL Number: MFCD00057986

PROPERTIES

• Biological Source: from synthetic
• Empirical Formula (Hill Notation): C41H78NO8P
• Purity: ≥97.0% (TLC)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Application
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents 1.
Biochem/physiol Actions
DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order.2 DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma3 and kidney4 cell lines (gene therapy).

Description (简体中文)

Application
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents 1.
Biochem/physiol Actions
DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order.2 DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma3 and kidney4 cell lines (gene therapy).