LWH-63 hydrochloride

• Catalog No.: L9167
• CAS Number: 276890-57-4
• M. F.: C24H35ClN4O
• M. W.: 431.0139
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-{ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}butan-1-ol hydrochloride
• IUPAC Traditional name: 4-{ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino}butan-1-ol hydrochloride
• Synonyms: 4-(N-Ethyl-n-4-hydroxybutyl)amino-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidine hydrochloride; NIH-3

DATABASE IDS

• PubChem SID: 24724529
• CAS Number: 276890-57-4
• MDL Number: MFCD07784506

PROPERTIES

• Empirical Formula (Hill Notation): C24H35ClN4O
• Purity: ≥98% (HPLC)
• Apperance: light brown solid
• Solubility: DMSO: ~10 mg/mL
• Solubility: H2O: insoluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Non-peptide CRF1 corticotrophin-releasing factor antagonist. Ki = 0.68 nM; blocks ethanol-induced effects as well as CRF effects in mice, suggesting a possible therapeutic target for the treatment of stress-induced alcohol drinking.

Description (简体中文)

Biochem/physiol Actions
Non-peptide CRF1 corticotrophin-releasing factor antagonist. Ki = 0.68 nM; blocks ethanol-induced effects as well as CRF effects in mice, suggesting a possible therapeutic target for the treatment of stress-induced alcohol drinking.