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LY-487379 hydrochloride_Molecular_structure_CAS_353229-59-1)
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LY-487379 hydrochloride

Catalog No. L1170 Name Sigma Aldrich
CAS Number 353229-59-1 Website http://www.sigmaaldrich.com
M. F. C21H20ClF3N2O4S Telephone 1-800-521-8956
M. W. 488.9077096 Fax
Purity ≥98% (HPLC) Email
Storage desiccated Chembase ID: 154480

SYNONYMS

IUPAC name
2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethane-1-sulfonamide hydrochloride
IUPAC Traditional name
2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide hydrochloride
Synonyms
N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine hydrochloride

DATABASE IDS

MDL Number MFCD11519970
CAS Number 353229-59-1

PROPERTIES

Empirical Formula (Hill Notation) C21H19F3N2O4SHCl
Purity ≥98% (HPLC)
Apperance off-white powder
Solubility DMSO: >20 mg/mL
MSDS Link Download
Storage Condition desiccated
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2. EC50 = 1.7 μM. LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2 and has no activity at human mGluR3. LY-487379 markedly potentiates glutamate-stimulated [35S]GTPγS binding in a concentration-dependent manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing the maximum levels of [35S]GTPγS stimulation. LY-487379 has anxiolytic effects in fear-potentiated startle. This activity profile is useful in all symptom domains of schizophrenia.1
Description (简体中文)
Biochem/physiol Actions
LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2. EC50 = 1.7 μM. LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2 and has no activity at human mGluR3. LY-487379 markedly potentiates glutamate-stimulated [35S]GTPγS binding in a concentration-dependent manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing the maximum levels of [35S]GTPγS stimulation. LY-487379 has anxiolytic effects in fear-potentiated startle. This activity profile is useful in all symptom domains of schizophrenia.1

REFERENCES