Bicyclol

• Catalog No.: B3313
• CAS Number: 118159-48-1
• M. F.: C19H18O9
• M. W.: 390.34082
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: methyl 4-[5-(hydroxymethyl)-7-methoxy-2H-1,3-benzodioxol-4-yl]-7-methoxy-2H-1,3-benzodioxole-5-carboxylate
• IUPAC Traditional name: methyl 4-[5-(hydroxymethyl)-7-methoxy-2H-1,3-benzodioxol-4-yl]-7-methoxy-2H-1,3-benzodioxole-5-carboxylate
• Synonyms: 4, 4′-dimethoxy-2, 3, 2′, 3′-bis(methylenedioxy)-6-hydroxymethyl-6′-methoxy-carbonyl biphenyl

DATABASE IDS

• MDL Number: MFCD00889471
• CAS Number: 118159-48-1

PROPERTIES

• Empirical Formula (Hill Notation): C19H18O9
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H400
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P273
• Risk Statements: 50/53
• RTECS: DT4312000
• Safety Statements: 60-61
• Storage Condition: desiccated
• Storage Temperature: 2-8°C

DETAILS

Description (English)

Biochem/physiol Actions
Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. The drug appears to protect against liver injury in animals. Recently it was reported that bicyclol induce the expression of hepatic HSP27 and HSP70, and thus consequently inhibits the transcription factor NF-?B-mediated apoptosis and necrosis in liver tissue. It appears that bicyclol induces hepatic HSP27 and HSP70 expression through activating transcription of HSPs genes.

Description (简体中文)

Biochem/physiol Actions
Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. The drug appears to protect against liver injury in animals. Recently it was reported that bicyclol induce the expression of hepatic HSP27 and HSP70, and thus consequently inhibits the transcription factor NF-?B-mediated apoptosis and necrosis in liver tissue. It appears that bicyclol induces hepatic HSP27 and HSP70 expression through activating transcription of HSPs genes.