YM-202074 sesquifumarate salt hydrate

• Catalog No.: Y1271
• CAS Number: 299900-84-8(anhydrous)
• M. F.: C74H100N12O15S3
• M. W.: 1493.8522
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: tris(N-cyclohexyl-11-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methyl-5-thia-2,7-diazatricyclo[6.4.0.0^2,^6]dodeca-1(12),3,6,8,10-pentaene-4-carboxamide) bis(but-2-enedioic acid) hydrate
• IUPAC Traditional name: tris(N-cyclohexyl-11-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methyl-5-thia-2,7-diazatricyclo[6.4.0.0^2,^6]dodeca-1(12),3,6,8,10-pentaene-4-carboxamide) bis(butenedioic acid) hydrate
• Synonyms: YM 202074; YM202074; N-cyclohexyl-6-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methylthiazolo[3,2-a]benzimidazole-2-carboxamide

DATABASE IDS

• MDL Number: MFCD16879020
• CAS Number: 299900-84-8(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C22H30N4O2S · 1.5C4H4O4 · xH2O
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >20 mg/mL
• Solubility: H2O: >5 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H319
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-36
• Safety Statements: 26-45
• Storage Temperature: room temp
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
YM-202074 is a potent and selective allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist. It bound an allosteric site of rat mGluR1 with a Ki value of 4.8 nM. It also inhibited the mGluR1-mediated inositol phosphates production in rat cerebellar granule cells with an IC50 value of 8.6 nM, while showing selectivity over mGluR(2-7).

Description (简体中文)

Biochem/physiol Actions
YM-202074 is a potent and selective allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist. It bound an allosteric site of rat mGluR1 with a Ki value of 4.8 nM. It also inhibited the mGluR1-mediated inositol phosphates production in rat cerebellar granule cells with an IC50 value of 8.6 nM, while showing selectivity over mGluR(2-7).