Tandospirone

• Catalog No.: T6704
• CAS Number: 87760-53-0
• M. F.: C21H29N5O2
• M. W.: 383.48726
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: (1R,2S,6R,7S)-4-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-4-azatricyclo[5.2.1.0^2,^6]decane-3,5-dione
• IUPAC Traditional name: tandospirone
• Synonyms: (1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-norbornanedicarboximide citrate salt; SM 3997

DATABASE IDS

• CAS Number: 87760-53-0

PROPERTIES

• Empirical Formula (Hill Notation): C21H29N5O2
• Purity: ≥98% (HPLC)
• Solubility: DMSO: soluble38 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Condition: protect from light
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Tandospirone is a partial agonist at 5HT1A receptors. It significantly reduces haloperidol-induced bradykinesia in a dose-dependent manner. The potency of tandospirone is equal to that of buspirone and approximate half that of diazepam. The potency of tandospirone as a dopamine antagonistic is less than 1/4 that of buspirone.

Description (简体中文)

Biochem/physiol Actions
Tandospirone is a partial agonist at 5HT1A receptors. It significantly reduces haloperidol-induced bradykinesia in a dose-dependent manner. The potency of tandospirone is equal to that of buspirone and approximate half that of diazepam. The potency of tandospirone as a dopamine antagonistic is less than 1/4 that of buspirone.