Salermide

• Catalog No.: S8825
• CAS Number: 1105698-15-4
• M. F.: C26H22N2O2
• M. W.: 394.46508
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: N-(3-{[(2-hydroxynaphthalen-1-yl)methylidene]amino}phenyl)-2-phenylpropanamide
• IUPAC Traditional name: N-(3-{[(2-hydroxynaphthalen-1-yl)methylidene]amino}phenyl)-2-phenylpropanamide
• Synonyms: N-{3-[(2-Hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide

DATABASE IDS

• CAS Number: 1105698-15-4
• MDL Number: MFCD12912446

PROPERTIES

• Empirical Formula (Hill Notation): C26H22N2O2
• Purity: ≥98% (HPLC)
• Apperance: powder, yellow
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H317-H412
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P273-P280
• Risk Statements: 43-52/53
• Safety Statements: 36/37-61
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942).

Description (简体中文)

Biochem/physiol Actions
Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942).