CRT0044876

• Catalog No.: C0496
• CAS Number: 6960-45-8
• M. F.: C9H6N2O4
• M. W.: 206.15494
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 7-nitro-1H-indole-2-carboxylic acid
• IUPAC Traditional name: 7-nitro-1H-indole-2-carboxylic acid
• Synonyms: 7-Nitroindole-2carboxylic acid; NSC 69877; 7-Nitro-1H-indole-2-carboxylic acid

DATABASE IDS

• EC Number: 230-154-6
• MDL Number: MFCD00044720
• CAS Number: 6960-45-8

PROPERTIES

• Empirical Formula (Hill Notation): C9H6N2O4
• Purity: ≥98% (HPLC)
• Apperance: powder
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H319-H334
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338-P342 + P311
• Risk Statements: 36-43
• Safety Statements: 26-36/37
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities-essential steps in excision repair-with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.

Description (简体中文)

Biochem/physiol Actions
CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities-essential steps in excision repair-with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.