LY2033298

• Catalog No.: L9919
• M. F.: C13H14ClN3O2S
• M. W.: 311.78716
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
• IUPAC Traditional name: 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
• Synonyms: 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methyl-thieno[2,3-b]pyridine-2-carboxamide

DATABASE IDS

• MDL Number: MFCD12912423

PROPERTIES

• Empirical Formula (Hill Notation): C13H14ClN3O2S
• Purity: ≥98% (HPLC)
• Apperance: off-white to tan solid
• Solubility: DMSO: >20 mg/mL
• European Hazard Symbols: Irritant (Xi)
• Risk Statements: 43
• Safety Statements: 36/37
• Storage Condition: desiccated
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 potentiates ACh-M4 binding, with no effect at M1/3/5 receptors. LY2033298 can also bind to the M ACh receptor, and mediate either positive or negative allosteric effects depending on the ligand used to probe receptor activity.1

Description (简体中文)

Biochem/physiol Actions
LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 potentiates ACh-M4 binding, with no effect at M1/3/5 receptors. LY2033298 can also bind to the M ACh receptor, and mediate either positive or negative allosteric effects depending on the ligand used to probe receptor activity.1