Oltipraz

• Catalog No.: O9389
• CAS Number: 64224-21-1
• M. F.: C8H6N2S3
• M. W.: 226.34164
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione
• IUPAC Traditional name: oltipraz
• Synonyms: 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione; BRN 0978110; CCRIS 4048; NSC 347901; RP 35972

DATABASE IDS

• EC Number: 264-736-6
• MDL Number: MFCD00868499
• CAS Number: 64224-21-1

PROPERTIES

• Empirical Formula (Hill Notation): C8H6N2S3
• Purity: ≥98% (HPLC)
• Apperance: red powder
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: JP1293000
• Safety Statements: 26-36/37
• Storage Condition: protect from light
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification genes encoding anti-oxidant and multidrug resistance-associated proteins to mediate its chemopreventive efficacy.

Description (简体中文)

Biochem/physiol Actions
Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification genes encoding anti-oxidant and multidrug resistance-associated proteins to mediate its chemopreventive efficacy.