cDPCP

• Catalog No.: C0996
• CAS Number: 106343-54-8
• M. F.: C5H11Cl2N3Pt
• M. W.: 379.14494
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: chloroplatinumylium pyridine diamine chloride
• IUPAC Traditional name: chloroplatinumylium pyridine diamine chloride
• Synonyms: cis-Diammine(pyridine)chloroplatinum(II) chloride; cis-[Pt(NH3)2(py)Cl]+ chloride; Pyriplatin

DATABASE IDS

• CAS Number: 106343-54-8
• MDL Number: MFCD12912400

PROPERTIES

• Empirical Formula (Hill Notation): C5H11Cl2N3Pt
• Purity: ≥98% (HPLC)
• Apperance: white to off-white solid
• Solubility: H2O: >10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H315-H317-H319-H334-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 22-36/37/38-42/43
• Safety Statements: 26-36-45
• Storage Temperature: 2-8°C
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent. It is a cationic monofunctional platinum(II) complex with unique chemical and biological properties. cDPCP binds covalently only to a single DNA base (the N7 atom of a single guanosine residue), and thus forms monofunctional rather than bifunctional lesions with DNA. cDPCP effectively blocks transcription from DNA templates carrying adducts of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds.

Description (简体中文)

Biochem/physiol Actions
cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent. It is a cationic monofunctional platinum(II) complex with unique chemical and biological properties. cDPCP binds covalently only to a single DNA base (the N7 atom of a single guanosine residue), and thus forms monofunctional rather than bifunctional lesions with DNA. cDPCP effectively blocks transcription from DNA templates carrying adducts of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds.