ER-27319

• Catalog No.: E0656
• M. F.: C20H22N2O5
• M. W.: 370.39908
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 10-(3-aminopropyl)-3,4-dimethyl-9,10-dihydroacridin-9-one; oxalic acid
• IUPAC Traditional name: 10-(3-aminopropyl)-3,4-dimethylacridin-9-one; oxalic acid
• Synonyms: 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate

DATABASE IDS

• PubChem SID: 24724472
• MDL Number: MFCD07784502

PROPERTIES

• Empirical Formula (Hill Notation): C20H22N2O5
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: soluble28 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302 + H312
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P280
• Risk Statements: 21/22
• Safety Statements: 24/25
• Storage Temperature: 2-8°C
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.
ER-27319 inhibits Syk activation with an IC50 = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.1

Description (简体中文)

Biochem/physiol Actions
Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.
ER-27319 inhibits Syk activation with an IC50 = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.1