BVT.948

• Catalog No.: B6060
• CAS Number: 39674-97-0
• M. F.: C14H11NO3
• M. W.: 241.24204
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 4-hydroxy-3,3-dimethyl-2H,3H,5H-benzo[g]indole-2,5-dione
• IUPAC Traditional name: 4-hydroxy-3,3-dimethylbenzo[g]indole-2,5-dione
• Synonyms: 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione

DATABASE IDS

• MDL Number: MFCD00616487
• CAS Number: 39674-97-0
• PubChem SID: 24724422

PROPERTIES

• Empirical Formula (Hill Notation): C14H11NO3
• Purity: ≥98% (HPLC)
• Apperance: red solid
• Solubility: DMSO: soluble18 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H317
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 43
• Safety Statements: 36/37
• Storage Condition: desiccated
• Storage Condition: protect from light
• Storage Condition: under inert gas
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.
Features and Benefits
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

Description (简体中文)

Biochem/physiol Actions
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.
Features and Benefits
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.