PRIMA-1

• Catalog No.: P0069
• CAS Number: 5608-24-2
• M. F.: C9H15NO3
• M. W.: 185.2203
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
• IUPAC Traditional name: 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
• Synonyms: 2,2-Bishydroxymethyl-1-aza-bicyclo[2.2.2]octan-3-one

DATABASE IDS

• MDL Number: MFCD04974196
• CAS Number: 5608-24-2

PROPERTIES

• Empirical Formula (Hill Notation): C9H15NO3
• Purity: ≥98% (HPLC)
• Apperance: white to off-white solid
• Solubility: H2O: >10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H334
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P342 + P311
• Risk Statements: 22-43
• Safety Statements: 36/37
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.

Description (简体中文)

Biochem/physiol Actions
PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.