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TDZD-8

Catalog No. T8325 Name Sigma Aldrich
CAS Number 327036-89-5 Website http://www.sigmaaldrich.com
M. F. C10H10N2O2S Telephone 1-800-521-8956
M. W. 222.2636 Fax
Purity ≥98% (HPLC) Email
Storage protect from light Chembase ID: 154405

SYNONYMS

IUPAC name
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
IUPAC Traditional name
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Synonyms
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

DATABASE IDS

MDL Number MFCD04973552
CAS Number 327036-89-5

PROPERTIES

German water hazard class 3
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H334
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements P261-P342 + P311
Risk Statements 43
Safety Statements 36/37
Storage Condition protect from light
Storage Temperature 2-8°C
Empirical Formula (Hill Notation) C10H10N2O2S
Purity ≥98% (HPLC)
Apperance white needles
Melting Point 63-64.4 °C
Solubility DMSO: >10 mg/mL

DETAILS

Description (English)
Biochem/physiol Actions
TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.
Description (简体中文)
Biochem/physiol Actions
TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

REFERENCES