TDZD-8

• Catalog No.: T8325
• CAS Number: 327036-89-5
• M. F.: C10H10N2O2S
• M. W.: 222.2636
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
• IUPAC Traditional name: 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
• Synonyms: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

DATABASE IDS

• MDL Number: MFCD04973552
• CAS Number: 327036-89-5

PROPERTIES

• German water hazard class: 3
• GHS Signal Word: Danger
• GHS Hazard statements: H334
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P342 + P311
• Risk Statements: 43
• Safety Statements: 36/37
• Storage Condition: protect from light
• Storage Temperature: 2-8°C
• Empirical Formula (Hill Notation): C10H10N2O2S
• Purity: ≥98% (HPLC)
• Apperance: white needles
• Melting Point: 63-64.4 °C
• Solubility: DMSO: >10 mg/mL

DETAILS

Description (English)

Biochem/physiol Actions
TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

Description (简体中文)

Biochem/physiol Actions
TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.