Glp-Asn-Pro-d-Tyr-d-Trp-NH2

• Catalog No.: G5297
• CAS Number: 882400-49-9
• M. F.: C34H40N8O8
• M. W.: 688.7302
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (3S)-4-[(2S)-2-{[(1R)-1-{[(1R)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}pyrrolidin-1-yl]-4-oxo-3-{[(2S)-5-oxopyrrolidin-2-yl]formamido}butanamide
• IUPAC Traditional name: (3S)-4-[(2S)-2-{[(1R)-1-{[(1R)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}pyrrolidin-1-yl]-4-oxo-3-{[(2S)-5-oxopyrrolidin-2-yl]formamido}butanamide
• Synonyms: JAK4D

DATABASE IDS

• MDL Number: MFCD11114385
• CAS Number: 882400-49-9

PROPERTIES

• Empirical Formula (Hill Notation): C34H40N8O8
• Purity: ≥98% (HPLC)
• Gene Information: rat ... TRH(7200), TRHDE(29953), TRHR(7201)
• Apperance: white solid
• Solubility: H2O: >2 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 2

DETAILS

Description (English)

Amino Acid Sequence
Glp-Asn-Pro-Tyr-Trp-NH2
Biochem/physiol Actions
The synthetic peptide Glp-Asn-Pro-d-Tyr-d-Trp-NH2 mimics and amplifies central actions of TRH in rat without releasing TSH. Glp-Asn-Pro-d-Tyr-d-Trp-NH2 has dual pharmacological activities: it inhibits TRH-DE and binds to central TRH receptors with nM affinity in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRH receptor 1 (TRHR1) or TRH receptor 2 (TRHR2). The peptide can be a potent tool for probing the role of TRH actions in the CNS and a platform for development of novel TRH-based therapeutics for neuro diseases.

Description (简体中文)

Amino Acid Sequence
Glp-Asn-Pro-Tyr-Trp-NH2
Biochem/physiol Actions
The synthetic peptide Glp-Asn-Pro-d-Tyr-d-Trp-NH2 mimics and amplifies central actions of TRH in rat without releasing TSH. Glp-Asn-Pro-d-Tyr-d-Trp-NH2 has dual pharmacological activities: it inhibits TRH-DE and binds to central TRH receptors with nM affinity in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRH receptor 1 (TRHR1) or TRH receptor 2 (TRHR2). The peptide can be a potent tool for probing the role of TRH actions in the CNS and a platform for development of novel TRH-based therapeutics for neuro diseases.