Dimebon dihydrochloride hydrate

• Catalog No.: D6196
• CAS Number: 97657-92-6(anhydrous)
• M. F.: C21H29Cl2N3O
• M. W.: 410.38046
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 5-(2-{2,8-dimethyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-5-yl}ethyl)-2-methylpyridine hydrate dihydrochloride
• IUPAC Traditional name: latrepirdine hydrate dihydrochloride
• Synonyms: Dimebolin dihydrochloride hydrate; Dimebone dihydrochloride hydrate; 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate; Dimeboline dihydrochloride hydrate

DATABASE IDS

• MDL Number: MFCD17215933
• CAS Number: 97657-92-6(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C21H25N3 · 2HCl · xH2O
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: H2O: ≥10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 22-36/38
• Safety Statements: 26-36/39
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

Description (简体中文)

Biochem/physiol Actions
Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.