HC-030031_Molecular_structure_CAS_349085-38-7)

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HC-030031
Catalog No.	H4415	Name	Sigma Aldrich
CAS Number	349085-38-7	Website	http://www.sigmaaldrich.com
M. F.	C18H21N5O3	Telephone	1-800-521-8956
M. W.	355.39104	Fax
Purity	≥98% (HPLC)	Email
Storage		Chembase ID: 154399

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SYNONYMS

IUPAC name

2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)-N-[4-(propan-2-yl)phenyl]acetamide

IUPAC Traditional name

2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-isopropylphenyl)acetamide

Synonyms

1,2,3,6-Tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide

2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

DATABASE IDS

MDL Number	MFCD02007349
CAS Number	349085-38-7

PROPERTIES

Empirical Formula (Hill Notation)	C18H21N5O3
Purity	≥98% (HPLC)
Apperance	off-white powder
Solubility	DMSO: soluble30 mg/mL
GHS Pictograms
GHS Signal Word	Danger
GHS Hazard statements	H301
European Hazard Symbols	Toxic (T)
MSDS Link	Download
Personal Protective Equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS Precautionary statements	P301 + P310
RID/ADR	UN 2811 6.1/PG 3
Risk Statements	25
Safety Statements	45
Storage Temperature	room temp
Hazard Class	6.1
UN Number	2811
Packing Group	3
German water hazard class	3

DETAILS

Description (English)

Biochem/physiol Actions
HC-030031 is a selective TRPA1 channel blocker, antagonizing formalin-evoked calcium influx and formalin-induced pain. IC50 is 5 μM. TRPA1 antagonism is a promising therapeutic target for chronic inflammatory or neurogenic pain.1
HC-030031 is a selective TRPA1 channel blocker. HC-030031 antagonizes formalin-evoked calcium influx. IC50 is 5 μM.

Description (简体中文)